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Deubiquitinase USP5 promotes non-small cell lung cancer cell proliferation by stabilizing cyclin D1

1 Oct 2021

Abstract excerpt

Background: Cyclin D1 (CCND1) is overexpressed in non-small cell lung cancer (NSCLC) and contributes to its tumorigenesis and progression. Accumulating evidence shows that ubiquitin-specific protease 5 (USP5), an important member of the USP family, acts as a tumor promoter by deubiquitinating and stabilizing oncoproteins. However, neither the mechanism for dysregulated turnover of CCND1 protein nor the...

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PMID: 34858787
DOI: 10.21037/tlcr-21-767

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