From Exposure to Biomarker: Cumulative Tobacco Burden and Integrated Multiomics Signatures of High Tumor Mutational Burden in Lung Adenocarcinoma-A Secondary Analysis of the Cancer Genome Atlas.

Abstract excerpt

Environmental exposures are upstream determinants of molecular variation, yet exposure-to-biomarker gradients remain insufficiently quantified in harmonized multiomics cancer cohorts. Using TCGA lung adenocarcinoma as a model, we evaluated cumulative tobacco exposure and smoking history as determinants of variant-derived biomarkers and tested whether integrating clinical, genomic, transcriptomic, and proteomic...

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