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Article

Genomic and molecular landscape of early onset colorectal cancer: Emerging insights and clinical implications-A systematic review.

Surgery - 1 Oct 2026

Kyrochristou Ilektra, Kyrochristou Gerasimia, Anagnostopoulos Georgios, Mitsis Michail, Bali Christina, Vlachos Konstantinos, Lianos Georgios D

Abstract excerpt

BACKGROUND: Early onset colorectal cancer, defined as colorectal malignancy occurring before age 50, has been rising globally. Increasing molecular evidence suggests that early onset colorectal cancer is not merely a premature form of late-onset colorectal cancer but a distinct biologic entity with unique genomic and transcriptomic profiles. METHODS: A systematic PubMed search using the terms "early onset...

Read the complete abstract on PubMed

Topics

Humans
Age of Onset
Biomarkers, Tumor
Colorectal Neoplasms
DNA Methylation
Genomics

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Mutation

Proto-Oncogene Mas

Source

Identifiers

PMID: 42492394
DOI: 10.1016/j.surg.2026.110430

Genes

DUSP1
EGR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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