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Host range and structural analysis of bat‐origin RshSTT182/200 coronavirus binding to human ACE2 and its animal orthologs

15 Dec 2022

Abstract excerpt

Bat-origin RshSTT182 and RshSTT200 coronaviruses (CoV) from Rhinolophus shameli in Southeast Asia (Cambodia) share 92.6% whole-genome identity with SARS-CoV-2 and show identical receptor-binding domains (RBDs). In this study, we determined the structure of the RshSTT182/200 receptor binding domain (RBD) in complex with human angiotensin-converting enzyme 2 (hACE2) and identified the key residues that influence...

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PMID: 36519268
DOI: 10.15252/embj.2022111737

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