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Article

Cross-species recognition of SARS-CoV-2 to bat ACE2

23 Dec 2020

Abstract excerpt

(bACE2-Rm) with substantially lower affinity compared with that to the human ACE2 (hACE2), and its infectivity to host cells expressing bACE2-Rm was confirmed with pseudotyped SARS-CoV-2 virus and SARS-CoV-2 wild virus. The structure of the SARS-CoV-2 RBD with the bACE2-Rm complex was determined, revealing a binding mode similar to that of hACE2. The analysis of binding details between SARS-CoV-2 RBD and bACE2-Rm...

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PMID: 33335073
DOI: 10.1073/pnas.2020216118

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