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Article

Monophosphoryl lipid A ameliorates radiation-induced lung injury by promoting the polarization of macrophages to the M1 phenotype.

Journal of translational medicine - 14 Dec 2022

Guo Xingdong, Du Lehui, Ma Na, Zhang Pei, Wang Yuan, Han Yanan, Huang Xiang, Zhang Qian, Tan Xin, Lei Xiao, Qu Baolin

Abstract excerpt

BACKGROUND: Radiation-induced lung injury (RILI) often occurs during clinical chest radiotherapy and acute irradiation from accidental nuclear leakage. This study explored the role of monophosphoryl lipid A (MPLA) in RILI. MATERIALS AND METHODS: The entire thoracic cavity of C57BL/6N mice was irradiated at 20 Gy with or without pre-intragastric administration of MPLA. HE staining, Masson trichrome staining, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 36517836
DOI: 10.1186/s12967-022-03804-x
PMCID: PMC9753357

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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