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Article

Developmental phenomics suggests that H3K4 monomethylation confers multi-level phenotypic robustness.

Cell reports - 13 Dec 2022

Gandara Lautaro, Tsai Albert, Ekelöf Måns, Galupa Rafael, Preger-Ben Noon Ella, Alexandrov Theodore, Crocker Justin

Abstract excerpt

How histone modifications affect animal development remains difficult to ascertain. Despite the prevalence of histone 3 lysine 4 monomethylation (H3K4me1) on enhancers, hypomethylation appears to have minor effects on phenotype and viability. Here, we genetically reduce H3K4me1 deposition in Drosophila melanogaster and find that hypomethylation reduces transcription factor enrichment in nuclear microenvironments,...

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Identifiers

PMID: 36516782
DOI: 10.1016/j.celrep.2022.111832
PMCID: PMC9764455

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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