Article
Reduced levels of two modifiers of epigenetic gene silencing, Dnmt3a and Trim28, cause increased phenotypic noise.
Genome biology - 1 Jan 2010
Whitelaw Nadia C, Chong Suyinn, Morgan Daniel K, Nestor Colm, Bruxner Timothy J, Ashe Alyson, Lambley Eleanore, Meehan Richard, Whitelaw Emma
Abstract excerpt
BACKGROUND: Inbred individuals reared in controlled environments display considerable variance in many complex traits but the underlying cause of this intangible variation has been an enigma. Here we show that two modifiers of epigenetic gene silencing play a critical role in the process. RESULTS: Inbred mice heterozygous for a null mutation in DNA methyltransferase 3a (Dnmt3a) or tripartite motif protein 28...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.