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Article

The histone code at a crossroads: history, context, and new approaches.

Trends in genetics : TIG - 1 Feb 2026

Jung Julie, Werner Michael S

Abstract excerpt

Recent studies have reported that catalytically dead histone-modifying enzymes can rescue the function of their null alleles. Histone 'replacement' experiments have similarly found a lack of phenotypes for some modifications. Do these findings foretell a paradigm shift for the histone code hypothesis? Here, we discuss these results through the lens of ecology, evolution, and development ('eco-evo-devo') to...

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Identifiers

PMID: 41087194
DOI: 10.1016/j.tig.2025.09.003
PMCID: PMC12614838

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