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Dual targeting of aberrant DNA and histone methylation synergistically suppresses tumor cell growth in ATL

14 Dec 2022

Abstract excerpt

Adult T-cell leukemia/lymphoma (ATL) is a malignancy of mature CD4+ T cells caused by human T-cell lymphotropic virus type 1 (HTLV-1)-induced T-cell transformation. After infection with HTLV-1, it takes several decades for HTLV-1 carriers to develop ATL. The prognosis of ATL remains poor despite several new agents being approved in the last few years. Recently, it has been noted that epigenetic abnormalities,...

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PMID: 36516085
DOI: 10.1182/bloodadvances.2022008362

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