Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Histone acetylation and DNA demethylation of T cells result in an anaplastic large cell lymphoma-like phenotype.

Haematologica - 1 Feb 2013

Joosten Maria, Seitz Volkhard, Zimmermann Karin, Sommerfeld Anke, Berg Erika, Lenze Dido, Leser Ulf, Stein Harald, Hummel Michael

Abstract excerpt

A characteristic feature of anaplastic large cell lymphoma is the significant repression of the T-cell expression program despite its T-cell origin. The reasons for this down-regulation of T-cell phenotype are still unknown. To elucidate whether epigenetic mechanisms are responsible for the loss...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Azacitidine
Share to B-Lymphocytes
Share to Decitabine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epigenesis, Genetic

Share to Gene Silencing

Share to Histones

Share to Hydroxamic Acids

Share to Lymphoma, Large-Cell, Anaplastic

Source

Open in PubMed Open full text

Identifiers

PMID: 22899583
DOI: 10.3324/haematol.2011.054619
PMCID: PMC3561432

Genes

GATA3
JUN
LCK
LGALS1
ZAP70

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22899583-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Histone acetylation and DNA demethylation of T cells result in an anaplastic large cell lymphoma-like phenotype.PMID 22899583Read ↗

Epigenetic Alterations That Are the Backbone of Immune Evasion in T-Cell MalignanciesSemantic proximity Read ↗

Histone acetylation and DNA demethylation of B cells result in a Hodgkin-like phenotype.Semantic proximity Read ↗

Insights into the Pathogenesis of Anaplastic Large-Cell Lymphoma through Genome-wide DNA Methylation ProfilingSemantic proximity Read ↗

NPM-ALK oncogenic tyrosine kinase controls T-cell identity by transcriptional regulation and epigenetic silencing in lymphoma cells.Semantic proximity Read ↗

Gene expression profiling of isolated tumour cells from anaplastic large cell lymphomas: insights into its cellular origin, pathogenesis and relation to Hodgkin lymphoma.Semantic proximity Read ↗

Mechanisms of Histone Deacetylase Inhibitor-Regulated Gene Expression in Cancer CellsSemantic proximity Read ↗

HDAC1 acts as a tumor suppressor in ALK-positive anaplastic large cell lymphoma: implications for HDAC inhibitor therapySemantic proximity Read ↗

Requirement of DNMT1 to orchestrate epigenomic reprogramming during NPM-ALK driven T cell lymphomagenesisSemantic proximity Read ↗

Inactivation of the putative ubiquitin-E3 ligase PDLIM2 in classical Hodgkin and anaplastic large cell lymphoma.Semantic proximity Read ↗

HDAC7 controls anti-viral and anti-tumor immunity by CD8 <sup>+</sup> T cellsSemantic proximity Read ↗

Epigenetic alterations and advancement of treatment in peripheral T-cell lymphoma.Semantic proximity Read ↗

Pharmacological restoration and therapeutic targeting of the B-cell phenotype in classical Hodgkin lymphoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.