Article
Carfilzomib potentiates CUDC-101-induced apoptosis in anaplastic thyroid cancer.
Oncotarget - 29 Mar 2016
Zhang Lisa, Boufraqech Myriem, Lake Ross, Kebebew Electron
Abstract excerpt
Anaplastic thyroid cancer (ATC) is one of the most aggressive human malignancies, with no effective treatment currently available. Previously, we identified agents active against ATC cells, both in vitro and in vivo, using quantitative high-throughput screening of 3282 clinically approved drugs and small molecules. Here, we report that combining two of these active agents, carfilzomib, a second-generation...
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