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Article

Epigenetic Modulation with Histone Deacetylase Inhibitors in Combination with Immunotherapy

1 Jun 2015

Abstract excerpt

Understanding the contribution of dysregulated gene silencing to epigenomic alterations in cancer development provides the rationale for the use of epigenetic modulators, such as histone deacetylase (HDAC) inhibitors, in cancer therapy. HDAC inhibitors have been approved as single agents for cutaneous and peripheral T-cell lymphoma and have shown promising activity in reversing therapy resistance in other tumor...

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PMID: 26111034
DOI: 10.2217/epi.15.16

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