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Article

β-Defensin 19/119 mediates sperm chemotaxis and is associated with idiopathic infertility

1 Dec 2022

Abstract excerpt

Sperm chemotaxis is required for guiding sperm toward the egg. However, the molecular identity of physiological chemoattractant and its involvement in infertility remain elusive. Here, we identify DEFB19/119 (mouse/human orthologs) as a physiological sperm chemoattractant. The epithelia of the female reproductive tract and the cumulus-oocyte complex secrete DEFB19/119 that elicits calcium mobilization via the...

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PMID: 36513070
DOI: 10.1016/j.xcrm.2022.100825

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