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Article

Deficient human β-defensin 1 underlies male infertility associated with poor sperm motility and genital tract infection

13 Aug 2014

Abstract excerpt

Genital tract infection and reduced sperm motility are considered two pivotal etiological factors for male infertility associated with leukocytospermia and asthenozoospermia, respectively. We demonstrate that the amount of human β-defensin 1 (DEFB1) in sperm from infertile men exhibiting either leukocytospermia or asthenozoospermia, both of which are associated with reduced motility and reduced bactericidal...

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PMID: 25122636
DOI: 10.1126/scitranslmed.3009071

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