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Self-Renewing CD8+ T-cell Abundance in Blood Associates with Response to Immunotherapy

13 Dec 2022

Abstract excerpt

Treatment with immune checkpoint blockade (ICB) often fails to elicit durable antitumor immunity. Recent studies suggest that ICB does not restore potency to terminally dysfunctional T cells, but instead drives proliferation and differentiation of self-renewing progenitor T cells into fresh, effector-like T cells. Antitumor immunity catalyzed by ICB is characterized by mobilization of antitumor T cells in...

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PMID: 36512052
DOI: 10.1158/2326-6066.cir-22-0524

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