Article
The stoichiometric production of IL-2 and IFN-γ mRNA defines memory T cells that can self-renew after adoptive transfer in humans.
Science translational medicine - 29 Aug 2012
Wang Anran, Chandran Smita, Shah Syed A, Chiu Yu, Paria Biman C, Aghamolla Tamara, Alvarez-Downing Melissa M, Lee Chyi-Chia Richard, Singh Sanmeet, Li Thomas, Dudley Mark E, Restifo Nicholas P, Rosenberg Steven A, Kammula Udai S
Abstract excerpt
Adoptive immunotherapy using ex vivo-expanded tumor-reactive lymphocytes can mediate durable cancer regression in selected melanoma patients. Analyses of these trials have associated the in vivo engraftment ability of the transferred cells with their antitumor efficacy. Thus, there is intensive clinical interest in the prospective isolation of tumor-specific T cells that can reliably persist after transfer....
Topics
- Autoimmune Diseases
- CD8-Positive T-Lymphocytes
- Cell Differentiation
- Cell Proliferation
- Cell Separation
- Cell Survival
- Cells, Cultured
- Dermatitis
- Female