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Optimization of the proliferation and persistency of CAR T cells derived from human induced pluripotent stem cells

12 Dec 2022

Abstract excerpt

The effectiveness of chimaeric antigen receptor (CAR) T-cell immunotherapies against solid tumours relies on the accumulation, proliferation and persistency of T cells at the tumour site. Here we show that the proliferation of CD8αβ cytotoxic CAR T cells in solid tumours can be enhanced by deriving and expanding them from a single human induced-pluripotent-stem-cell clone bearing a CAR selected for efficient...

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PMID: 36509913
DOI: 10.1038/s41551-022-00969-0

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