Article
Overexpression of notch signaling in renin cells leads to a polycystic kidney phenotype.
Clinical science (London, England : 1979) - 13 Jan 2023
Belyea Brian C, Xu Fang, Wiltsie Margaret, Fountain Hayes, Charlton Jennifer, Fogo Agnes B, Sequeira-Lopez Maria Luisa Soledad, Gomez Roberto Ariel
Abstract excerpt
Polycystic kidney disease (PKD) is an inherited disorder that results in large kidneys, numerous fluid-filled cysts, and ultimately end-stage kidney disease. PKD is either autosomal dominant caused by mutations in PKD1 or PKD2 genes or autosomal recessive caused by mutations in the PKHD1 or DZIP1L genes. While the genetic basis of PKD is known, the downstream molecular mechanisms and signaling pathways that lead...
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