Protein as evolvable functionally constrained amorphous matter.

Abstract excerpt

We explore current ideas around the representation of a protein as an amorphous material, in turn represented by an abstract graph G with edges weighted by elastic stiffnesses. By embedding this graph in physical space, we can map every graph to a spectrum of conformational fluctuations and responses (as a result of, say, ligandbinding). This sets up a 'genotype-phenotype' map, which we use to evolve the...

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