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Article

High-Dimensional Mutant and Modular Thermodynamic Cycles, Molecular Switching, and Free Energy Transduction.

Annual review of biophysics - 22 May 2017

Carter Charles W

Abstract excerpt

Understanding how distinct parts of proteins produce coordinated behavior has driven and continues to drive advances in protein science and enzymology. However, despite consensus about the conceptual basis for allostery, the idiosyncratic nature of allosteric mechanisms resists general approaches. Computational methods can identify conformational transition states from structural changes, revealing common...

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PMID: 28375734
DOI: 10.1146/annurev-biophys-070816-033811
PMCID: PMC5472044

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