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Article

Mutational Status of SMAD4 and FBXW7 Affects Clinical Outcome in TP53–Mutated Metastatic Colorectal Cancer

30 Nov 2022

Abstract excerpt

Next–generation sequencing (NGS) provides a molecular rationale to inform prognostic stratification and to guide personalized treatment in cancer patients. Here, we determined the prognostic and predictive value of actionable mutated genes in metastatic colorectal cancer (mCRC). Among a total of 294 mCRC tumors examined by targeted NGS, 200 of them derived from patients treated with first–line chemotherapy...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 36497403
DOI: 10.3390/cancers14235921

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