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Article

BRCA-CRisk: A Contralateral Breast Cancer Risk Prediction Model for BRCA Carriers.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 10 Feb 2023

Sun Jie, Chu Futao, Pan Jiani, Zhang Yaxin, Yao Lu, Chen Jiuan, Hu Li, Zhang Juan, Xu Ye, Wang Xiaojia, Cao Wenming, Xie Yuntao

Abstract excerpt

PURPOSE: The absolute cumulative risk of contralateral breast cancer (CBC) for patients with BRCA1/2 variants is unknown. The purpose of this study was to develop a CBC risk prediction model for assessing CBC risk for BRCA1/2 carriers. METHODS: The primary cohort of 491 patients with BRCA1/2 variants was derived from a large series of unselected patients with breast cancer. A nomogram was established on the basis...

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PMID: 36480783
DOI: 10.1200/JCO.22.00833

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