Article
Contralateral breast cancer risk in BRCA1 and BRCA2 mutation carriers.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 10 Dec 2009
Graeser Monika K, Engel Christoph, Rhiem Kerstin, Gadzicki Dorothea, Bick Ulrich, Kast Karin, Froster Ursula G, Schlehe Bettina, Bechtold Astrid, Arnold Norbert, Preisler-Adams Sabine, Nestle-Kraemling Carolin, Zaino Mohammad, Loeffler Markus, Kiechle Marion, Meindl Alfons, Varga Dominic, Schmutzler Rita K
Abstract excerpt
PURPOSE: To estimate the risk for contralateral breast cancer in members of BRCA1- and BRCA2-positive families and to determine predictive risk factors. PATIENTS AND METHODS: A retrospective, multicenter, cohort study was performed from 1996 until 2008 and comprised 2,020 women with unilateral breast cancer (index patients, n = 978; relatives, n = 1.42) from 978 families who had a BRCA1 or BRCA2 mutation. Cox...
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