Article
The risk of contralateral breast cancer in patients from BRCA1/2 negative high risk families as compared to patients from BRCA1 or BRCA2 positive families: a retrospective cohort study.
Breast cancer research : BCR - 7 Dec 2012
Rhiem Kerstin, Engel Christoph, Graeser Monika, Zachariae Silke, Kast Karin, Kiechle Marion, Ditsch Nina, Janni Wolfgang, Mundhenke Christoph, Golatta Michael, Varga Dominic, Preisler-Adams Sabine, Heinrich Tilman, Bick Ulrich, Gadzicki Dorothea, Briest Susanne, Meindl Alfons, Schmutzler Rita K
Abstract excerpt
INTRODUCTION: While it has been reported that the risk of contralateral breast cancer in patients from BRCA1 or BRCA2 positive families is elevated, little is known about contralateral breast cancer risk in patients from high risk families that tested negative for BRCA1/2 mutations. METHODS: A retrospective, multicenter cohort study was performed from 1996 to 2011 and comprised 6,235 women with unilateral breast...
Topics
- Age Factors
- BRCA1 Protein
- BRCA2 Protein
- Breast
- Breast Neoplasms
- Cohort Studies
- Female
- Genetic Predisposition to Disease
- Humans