Article
Small RNA-based silencing strategies for transposons in the process of invading Drosophila species.
RNA (New York, N.Y.) - 1 Aug 2010
Rozhkov Nikolay V, Aravin Alexei A, Zelentsova Elena S, Schostak Natalia G, Sachidanandam Ravi, McCombie W Richard, Hannon Gregory J, Evgen'ev Michael B
Abstract excerpt
Colonization of a host by an active transposon can increase mutation rates or cause sterility, a phenotype termed hybrid dysgenesis. As an example, intercrosses of certain Drosophila virilis strains can produce dysgenic progeny. The Penelope element is present only in a subset of laboratory strains and has been implicated as a causative agent of the dysgenic phenotype. We have also introduced Penelope into...
Topics
- Animals
- Chimera
- Drosophila
- Drosophila melanogaster
- Germ Cells
- Mutation
- RNA
- RNA Interference
- RNA, Small Interfering
- RNA, Untranslated
- Retroelements