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Article

Generation of three induced pluripotent stem cell lines carrying different variants of the BDNF (Val66Met) polymorphism.

Stem cell research - 1 Feb 2023

Horschitz Sandra, Frank Josef, Koch Philipp

Abstract excerpt

Brain-derived neurotrophic factor (BDNF) has been implicated in a multitude of neurodevelopmental processes including neuronal differentiation, axonal outgrowth, synaptic plasticity, or survival. One human-specific single nucleotide polymorphism (rs6265) in the BDNF gene causes a substitution of valine (Val) to methionine (Met) at codon 66 in the pro domain of the protein (Val66Met). This substitution is...

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PMID: 36473250
DOI: 10.1016/j.scr.2022.102989

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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