Article
Cellular senescence marker p16INK4a and NFKB1 gene polymorphisms in lower gastro-intestinal acute graft versus host disease.
Transplant immunology - 1 Feb 2023
Kuba Adam, Raida Ludek, Brychtova Svetlana, Flodr Patrik, Mrazek Frantisek, Kriegova Eva, Faber Edgar, Papajik Tomas
Abstract excerpt
BACKGROUND: Lower gastrointestinal (GI) graft versus host disease (GVHD) represents a severe complication in allogeneic hematopoietic stem cell transplant (HSCT) recipients with high rates of transplant-related mortality. Deregulated innate immunity reactions are the features of its pathogenesis. Cellular senescence has been considered a program of the innate immunity. We focused on lower GI GVHD from the...
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