Article
High incidence of extensive chronic graft-versus-host disease in patients with the REG3A rs7588571 non-GG genotype.
PloS one - 1 Jan 2017
Koyama Daisuke, Murata Makoto, Hanajiri Ryo, Okuno Shingo, Kamoshita Sonoko, Julamanee Jakrawadee, Takagi Erina, Hirano Daiki, Miyao Kotaro, Sakemura Reona, Goto Tatsunori, Hayakawa Fumihiko, Seto Aika, Ozawa Yukiyasu, Miyamura Koichi, Terakura Seitaro, Nishida Tetsuya, Kiyoi Hitoshi
Abstract excerpt
Regenerating islet-derived protein 3 alpha (REG3A) is a biomarker of lower gastrointestinal graft-versus-host disease (GVHD); however, the biological role of REG3A in the pathophysiology of GVHD is not understood. Here, we examined the association between a single nucleotide polymorphism in the REG3A gene, rs7588571, which is located upstream and within 2 kb of the REG3A gene, and transplant outcomes including...
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