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Understanding and Targeting the Epigenetic Regulation to Overcome EGFR-TKIs Resistance in Human Cancer.

Recent patents on anti-cancer drug discovery - 1 Jan 2023

Sun Lan, Gao Lingyue, Zhao Yingxi, Wang Yuqing, Xu Qianhui, Zheng Yiru, Chen Jiali, Wang He, Wang Lihui

Abstract excerpt

BACKGROUND: The occurrence and progression of cancer are the results of the dysregulation of genetics and epigenetics. Epigenetic regulation can reversibly affect gene transcription activity without changing DNA structure. Covalent modification of histones is crucial in the epigenetic regulation of gene expression. Furthermore, epidermal growth factor receptor (EGFR) significantly affects cell tumorigenesis,...

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Identifiers

PMID: 36464873
DOI: 10.2174/1574892818666221201145810

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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