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Article

Genetic alterations shaping tumor response to anti-EGFR therapies.

Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy - 1 Sept 2022

Vaquero Javier, Pavy Allan, Gonzalez-Sanchez Ester, Meredith Mark, Arbelaiz Ander, Fouassier Laura

Abstract excerpt

The Epidermal Growth Factor Receptor (EGFR) has been targeted through the development of selective tyrosine kinase inhibitors (TKIs) and monoclonal antibodies (mAb). These molecules have shown effectiveness in a subset of patients with specific genetic alterations (i.e. gain-of-function EGFR mutations or EGFR gene amplification) and have been approved for their use in non-small-cell lung cancer (NSCLC),...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36063655
DOI: 10.1016/j.drup.2022.100863

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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