Article
Epigenetic alternations and cancer chemotherapy response.
Cancer chemotherapy and pharmacology - 1 Apr 2016
Lv Jin-Feng, Hu Lei, Zhuo Wei, Zhang Cong-Min, Zhou Hong-Hao, Fan Lan
Abstract excerpt
Epigenetics, referring to alterations in gene expression without a change in nucleotide sequence in eukaryotes, mainly includes DNA methylation, miRNA and histone modification. In recent years, accumulating evidences have shown that epigenetic aberrations not only play important roles in the initiation and development of human cancers but also affect cancer chemotherapy response by altering the expression of key...
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