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A Review on the Therapeutic Role of TKIs in Case of CML in Combination With Epigenetic Drugs

22 Oct 2021

Abstract excerpt

Chronic myeloid leukemia is a malignancy of bone marrow that affects white blood cells. There is strong evidence that disease progression, treatment responses, and overall clinical outcomes of CML patients are influenced by the accumulation of other genetic and epigenetic abnormalities, rather than only the BCR/ABL1 oncoprotein. Both genetic and epigenetic factors influence the efficacy of CML treatment...

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PMID: 34745216
DOI: 10.3389/fgene.2021.742802

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