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Article

Genetic variants found in paediatric oncology patients with severe chemotherapy-induced toxicity: A case series.

Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners - 1 Jul 2023

Bernsen E C, Hanff L M, Haveman L M, Tops Bbj, van der Lee M, Swen J J, Huitema Adr, Diekstra Mhm

Abstract excerpt

Paediatric oncology patients who develop severe chemotherapy-induced toxicity that requires dose reduction, delay or termination of treatment are at risk of decreased treatment efficacy. Previous research has provided evidence that genetic variants in TPMT, NUDT15, UGT1A1 and DPYD are associated with toxicity of anticancer drugs. This led to pharmacogenetic guidelines that are integrated into clinical practice in...

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PMID: 36464835
DOI: 10.1177/10781552221137302

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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