Article
Implementation of paediatric precision oncology into clinical practice: The Individualized Therapies for Children with cancer program 'iTHER'.
European journal of cancer (Oxford, England : 1990) - 1 Nov 2022
Langenberg Karin P S, Meister Michael T, Bakhuizen Jette J, Boer Judith M, van Eijkelenburg Natasha K A, Hulleman Esther, Ilan Uri, Looze Eleonora J, Dierselhuis Miranda P, van der Lugt Jasper, Breunis Willemijn, Schild Linda G, Ober Kimberley, van Hooff Sander R, Scheijde-Vermeulen Marijn A, Hiemcke-Jiwa Laura S, Flucke Uta E, Kranendonk Mariette E G, Wesseling Pieter, Sonneveld Edwin, Punt Simone, Boltjes Arjan, van Dijk Freerk, Verwiel Eugene T P, Volckmann Richard, Hehir-Kwa Jayne Y, Kester Lennart A, Koudijs Marco M J, Waanders Esme, Holstege Frank C P, Vormoor H Josef, Hoving Eelco W, van Noesel Max M, Pieters Rob, Kool Marcel, Stumpf Miriam, Blattner-Johnson Mirjam, Balasubramanian Gnana P, Van Tilburg Cornelis M, Jones Barbara C, Jones David T W, Witt Olaf, Pfister Stefan M, Jongmans Marjolijn C J, Kuiper Roland P, de Krijger Ronald R, Wijnen Marc H W, den Boer Monique L, Zwaan C Michel, Kemmeren Patrick, Koster Jan, Tops Bastiaan B J, Goemans Bianca F, Molenaar Jan J
Abstract excerpt
iTHER is a Dutch prospective national precision oncology program aiming to define tumour molecular profiles in children and adolescents with primary very high-risk, relapsed, or refractory paediatric tumours. Between April 2017 and April 2021, 302 samples from 253 patients were included. Comprehensive molecular profiling including low-coverage whole genome sequencing (lcWGS), whole exome sequencing (WES), RNA...
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