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A tissue specific-infection mouse model of SARS-CoV-2

20 Apr 2023

Abstract excerpt

Abstract Animal models play crucial roles in the rapid development of vaccines/drugs for the prevention and therapy of COVID-19, but current models have some deficits when studying the pathogenesis of SARS-CoV-2 on some special tissues or organs. Here, we generated a human ACE2 and SARS-CoV-2 NF/F knockin mouse line that constitutively expresses human ACE2 and specifically expresses SARS-CoV-2 N gene induced by...

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PMID: 37080957
DOI: 10.1038/s41421-023-00536-0

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