Article
Mutations in SARS-CoV-2 spike protein impair epitope-specific CD4+ T cell recognition.
Nature immunology - 1 Dec 2022
Tye Emily X C, Jinks Elizabeth, Haigh Tracey A, Kaul Baksho, Patel Prashant, Parry Helen M, Newby Maddy L, Crispin Max, Kaur Nayandeep, Moss Paul, Drennan Samantha J, Taylor Graham S, Long Heather M
Abstract excerpt
CD4+ T cells are essential for protection against viruses, including SARS-CoV-2. The sensitivity of CD4+ T cells to mutations in SARS-CoV-2 variants of concern (VOCs) is poorly understood. Here, we isolated 159 SARS-CoV-2-specific CD4+ T cell clones from healthcare workers previously infected with wild-type SARS-CoV-2 (D614G) and defined 21 epitopes in spike, membrane and nucleoprotein. Lack of CD4+ T cell...
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