Article

Natural heteroclitic-like peptides are generated by SARS-CoV-2 mutations

2022-10-28

Abstract excerpt

<h4>ABSTRACT</h4> Mutations carried by SARS-CoV-2 spike protein variants may promote viral escape from immune protection. Humoral immunity is sensitive to evasion by SARS-CoV-2 mutants, but the impact of viral evolution on the interplay between virus and host CD8 T cell reactivity remains uncertain. By a systematic functional analysis of 30 spike variant mutations, we show that in vaccinated as well as convalesce...

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Literature Corpus work: e1c99935-78a1-526a-ad6f-ed8bca2448e1
DOI: 10.1101/2022.10.28.513849

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