Article

CD8+ T Cell Epitope Variations Suggest a Potential Antigen Presentation Deficiency for Spike Protein of SARS-CoV-2

2020-10-28

Abstract excerpt

COVID-19 is caused by a newly identified coronavirus, SARS-CoV-2, and has become a pandemic around the world. The illustration of the immune responses against SARS-CoV-2 is urgently needed for understanding the pathogenesis of the disease and its vaccine development. CD8+ T cells are critical for virus clearance and induce long lasting protection in the host. Here we identified specific HLA-A2 restricted T cell ep...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 22b0d6ff-97ff-5b07-8201-286817d0366e
DOI: 10.2139/ssrn.3720772

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

CD8+ T Cell Epitope Variations Suggest a Potential Antigen Presentation Deficiency for Spike Protein of SARS-CoV-2DOI 10.2139/ssrn.3720772Read

CD8+ T cell epitope variations suggest a potential antigen presentation deficiency for spike protein of SARS-CoV-2Semantic proximity Read

SARS-CoV-2 Spike Protein-Derived Immunogenic Peptides that are Promiscuously Presented by Several HLA-Class II Molecules and Their Potential for Inducing Acquired ImmunitySemantic proximity Read

Identification of a promiscuous conserved CTL epitope within the SARS-CoV-2 spike proteinSemantic proximity Read

Prediction of SARS-CoV2 spike protein epitopes reveals HLA-associated susceptibilitySemantic proximity Read

Identification of a Promiscuous Conserved CTL Epitope Within the SARS-CoV-2 Spike ProteinSemantic proximity Read

Immunodominant T-cell epitopes from the SARS-CoV-2 spike antigen reveal robust pre-existing T-cell immunity in unexposed individualsSemantic proximity Read

CD8 T cell epitope generation toward the continually mutating SARS-CoV-2 spike protein in genetically diverse human population: Implications for disease control and prevention.Semantic proximity Read

COVID-19 Patients Form Memory CD8+ T Cells that Recognize a Small Set of Shared Immunodominant Epitopes in SARS-CoV-2Semantic proximity Read

CD8 T cell epitope generation toward the continually mutating SARS-CoV-2 spike protein in genetically diverse human population: Implications for disease control and preventionSemantic proximity Read

Bioinformatic prediction of potential T cell epitopes for SARS-Cov-2.Semantic proximity Read

Mutations in spike protein T cell epitopes of SARS-COV-2 variants: Plausible influence on vaccine efficacy.Semantic proximity Read

The SARS-COV-2 T-Cell Immunity is Directed Against the Spike, Membrane, and Nucleocapsid Protein and Associated with COVID 19 SeveritySemantic proximity Read