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Broad cross-T cell immunity between emerging SARS-CoV-2 serotypes waved by spike-signature mutations.

Emerging microbes & infections - 1 Dec 2026

Guo Yuanyuan, Tian Jinmin, Guo Peipei, Wang Xin, Shang Bingli, She Junying, Yang Mengjie, Gao George F, Liu Jun

Abstract excerpt

Since its emergence in late 2019, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has continuously threatened human health through constantly arising variants with iterative immune escape abilities. While SARS-CoV-2 variants have been recently classified into six serotypes based on cross-reactive antibody responses, T cell response features against these serotypes remain largely unknown. We evaluated...

Topics

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COVID-19
Cross Reactions
Epitopes, T-Lymphocyte
Mutation
SARS-CoV-2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Spike Glycoprotein, Coronavirus

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Open in PubMed Open full text

Identifiers

PMID: 41566607
DOI: 10.1080/22221751.2025.2610856
PMCID: PMC12829424

Genes

CD4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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