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Article

Decoupling dedifferentiation and G2/M arrest in kidney fibrosis

30 Nov 2022

Abstract excerpt

Understanding the cellular mechanisms underlying chronic kidney disease (CKD) progression is required to develop effective therapeutic approaches. In this issue of the JCI, Taguchi, Elias, et al. explore the relationship between cyclin G1 (CG1), an atypical cyclin that induces G2/M proximal tubule cell cycle arrest, and epithelial dedifferentiation during fibrogenesis. While CG1-knockout mice were protected from...

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PMID: 36453550
DOI: 10.1172/jci163846

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