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HDAC9-mediated epithelial cell cycle arrest in G2/M contributes to kidney fibrosis in male mice

25 May 2023

Abstract excerpt

Renal tubular epithelial cells (TECs) play a key role in kidney fibrosis by mediating cycle arrest at G2/M. However, the key HDAC isoforms and the underlying mechanism that are involved in G2/M arrest of TECs remain unclear. Here, we find that Hdac9 expression is significantly induced in the mouse fibrotic kidneys, especially in proximal tubules, induced by aristolochic acid nephropathy (AAN) or unilateral ureter...

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PMID: 37230975
DOI: 10.1038/s41467-023-38771-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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