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Targeting RAS signaling pathway as a potential therapeutic target in the treatment of colorectal cancer

6 Mar 2017

Abstract excerpt

The V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS) is frequently dysregulated in colorectal cancer (CRC). It is involved in the modulation of several downstream effectors, that include: Raf/Mek/Erk, PI3K/Akt, RalGDS/p38MAPK, and Rac/Rho, and thereby influences tumorigenesis, the invasive behaviors of tumor cell, and resistance to therapy. There is growing evidence exploring the use of drugs that...

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PMID: 28262927
DOI: 10.1002/jcp.25890

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