Article
Generation of a human induced pluripotent stem cell line (INEUi001-A) from an amyotrophic lateral sclerosis/frontotemporal dementia patient with a C9ORF72 G4C2 genotype of <2 (GGGGCCG) and 10 repeats.
Stem cell research - 1 Jun 2023
Nievas Micaela, Romorini Leonardo, Isaja Luciana, Clas Giulia S, Rodríguez-Varela Soledad, Mucci Sofía, Itzcovich Tatiana, de Ambrosi Bruno, Scassa María E, Sevlever Gustavo E, Surace Ezequiel I, Marazita Mariela C
Abstract excerpt
Human induced pluripotent stem cell (hiPSC) line INEUi001-A was reprogrammed from peripheral blood mononuclear cells (PBMC) using the lentiviral-hSTEMCCA-loxP vector. PBMCs were obtained from a 75- year-old female ALS/FTD disease patient carrying a heterozygous deletion within the C9ORF72 hexanucleotide repeat region resulting in a GGGGCCG sequence (∼1.16 repeats). C9ORF72 genotype was maintained and stemness and...
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