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Article

DNA-methylation signature accurately differentiates pancreatic cancer from chronic pancreatitis in tissue and plasma

14 Sept 2023

Abstract excerpt

OBJECTIVE: Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy. Differentiation from chronic pancreatitis (CP) is currently inaccurate in about one-third of cases. Misdiagnoses in both directions, however, have severe consequences for patients. We set out to identify molecular markers for a clear distinction between PDAC and CP. DESIGN: Genome-wide variations of DNA-methylation, messenger RNA and...

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PMID: 37709492
DOI: 10.1136/gutjnl-2023-330155

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