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Article

Disentangling the aetiological pathways between body mass index and site-specific cancer risk using tissue-partitioned Mendelian randomisation.

British journal of cancer - 1 Feb 2023

Leyden Genevieve M, Greenwood Michael P, Gaborieau Valérie, Han Younghun, Amos Christopher I, Brennan Paul, Murphy David, Davey Smith George, Richardson Tom G

Abstract excerpt

BACKGROUND: Body mass index (BMI) is known to influence the risk of various site-specific cancers, however, dissecting which subcomponents of this heterogenous risk factor are predominantly responsible for driving disease effects has proven difficult to establish. We have leveraged tissue-specific gene expression to separate the effects of distinct phenotypes underlying BMI on the risk of seven site-specific...

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Identifiers

PMID: 36434155
DOI: 10.1038/s41416-022-02060-6
PMCID: PMC9938133

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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