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Article

Adiposity distribution and risks of 12 obesity-related cancers: a Mendelian randomization analysis.

Journal of the National Cancer Institute - 1 Dec 2025

Hazelwood Emma, Goudswaard Lucy J, Lee Matthew A, Vabistsevits Marina, Pournaras Dimitri J, Brenner Hermann, Buchanan Daniel D, Gruber Stephen B, Gsur Andrea, Li Li, Vodickova Ludmila, Grant Robert C, Samadder N Jewel, Timpson Nicholas J, Gunter Marc J, Schuster-Böckler Benjamin, Yarmolinsky James, Richardson Tom G, Freisling Heinz, Murphy Neil, Vincent Emma E

Abstract excerpt

INTRODUCTION: There is convincing evidence that overall adiposity increases the risks of several cancers. Whether the distribution of adiposity plays a similar role is unclear. METHODS: We used 2-sample Mendelian randomization (MR) to examine causal relationships of 5 adiposity distribution traits (abdominal subcutaneous adipose tissue (ASAT); visceral adipose tissue (VAT); gluteofemoral adipose tissue (GFAT);...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40987470
DOI: 10.1093/jnci/djaf201
PMCID: PMC12682385

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