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Article

A selective p53 activator and anticancer agent to improve colorectal cancer therapy

1 Apr 2021

Abstract excerpt

Impairment of the p53 pathway is a critical event in cancer. Therefore, reestablishing p53 activity has become one of the most appealing anticancer therapeutic strategies. Here, we disclose the p53-activating anticancer drug (3S)-6,7-bis(hydroxymethyl)-5-methyl-3-phenyl-1H,3H-pyrrolo[1,2-c]thiazole (MANIO). MANIO demonstrates a notable selectivity to the p53 pathway, activating wild-type (WT)p53 and restoring...

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Identifiers

PMID: 33852837
DOI: 10.1016/j.celrep.2021.108982

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