Article
Recent Synthetic Approaches towards Small Molecule Reactivators of p53.
Biomolecules - 20 Apr 2020
Silva Jerson L, Lima Carolina G S, Rangel Luciana P, Ferretti Giulia D S, Pauli Fernanda P, Ribeiro Ruan C B, da Silva Thais de B, da Silva Fernando C, Ferreira Vitor F
Abstract excerpt
The tumor suppressor protein p53 is often called "the genome guardian" and controls the cell cycle and the integrity of DNA, as well as other important cellular functions. Its main function is to trigger the process of apoptosis in tumor cells, and approximately 50% of all cancers are related to the inactivation of the p53 protein through mutations in the TP53 gene. Due to the association of mutant p53 with...
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