Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Rescue of the apoptotic-inducing function of mutant p53 by small molecule RITA.

Cell cycle (Georgetown, Tex.) - 1 May 2010

Zhao Carolyn Y, Grinkevich Vera V, Nikulenkov Fedor, Bao Wenjie, Selivanova Galina

Abstract excerpt

Expression of mutant p53 correlates with poor prognosis in many tumors, therefore strategies aimed at reactivation of mutant p53 are likely to provide important benefits for treatment of tumors that are resistant to chemotherapy and radiotherapy. We have previously identified and characterized a small molecule RITA which binds p53 and induces a conformational change which prevents the binding of p53 to several...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apoptosis
Share to Cell Line, Tumor
Share to Cell Proliferation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Furans

Share to Neoplasms

Share to Proto-Oncogene Proteins c-mdm2

Share to Transcriptional Activation

Share to Tumor Suppressor Protein p53

Source

Identifiers

PMID: 20436301
DOI: 10.4161/cc.9.9.11545

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rescue of the apoptotic-inducing function of mutant p53 by small molecule RITA.PMID 20436301Read ↗

Dual targeting of wild-type and mutant p53 by small molecule RITA results in the inhibition of N-Myc and key survival oncogenes and kills neuroblastoma cells in vivo and in vitro.Semantic proximity Read ↗

Novel cancer therapy by reactivation of the p53 apoptosis pathway.Semantic proximity Read ↗

Chemical Variations on the p53 Reactivation ThemeSemantic proximity Read ↗

RITA displays anti-tumor activity in medulloblastomas independent of TP53 status.Semantic proximity Read ↗

Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound.Semantic proximity Read ↗

Pharmacological targeting of p53 through RITA is an effective antitumoral strategy for malignant pleural mesothelioma.Semantic proximity Read ↗

Small molecules that reactivate mutant p53.Semantic proximity Read ↗

Therapeutics Targeting p53-MDM2 Interaction to Induce Cancer Cell DeathSemantic proximity Read ↗

A new family of small molecules to probe the reactivation of mutant p53.Semantic proximity Read ↗

Restoring p53 function in cancer: novel therapeutic approaches for applying the brakes to tumorigenesis.Semantic proximity Read ↗

Patented inhibitors of p53–Mdm2 interaction (2006 – 2008)Semantic proximity Read ↗

Mutated and non-mutated TP53 as targets in the treatment of leukaemia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.